"There will be no change".
The visitors then collapsed after the break, their downfall starting when Bravo came out of his area and lost the ball to Suarez before using his hands to stop the Uruguayan's attempted chip.
"I know from the beginning when Claudio is going to make a mistake, he will be on the front page", Guardiola said.
Guardiola said: "I spoke with Sergio, we talked about that".
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The 45-year-old said his side needed more time to be capable of challenging at Barcelona's level.
"Today was a very hard game against Barca, but we did not deserve to lose 4-0". We are a new club, we are in the process of getting to know each other and we are a club who weren't in Europe for 35 years.
"It is always hard to play in Barcelona with 11 players, and with 10 the game was over", said Guardiola.
City have now gone four games without a win in all competitions after winning their previous 10 at the start of the season.
"He was involved in all the game's key moments".
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Kompany was surprisingly left out of the squad of 18 in the Nou Camp in midweek after admitting he didn't feel right mentally, despite being physically fit.
Bayern Munich also romped to a 4-1 victory over PSV Eindhoven in Group D, recovering some esteem after losing to leader Atletico Madrid in its last European game and drawing twice in the Bundesliga.
There is believed to be tension between the pair and fan hero Aguero, whose stoppage-time goal in the last match of the season made the Blues champions back in 2012, faces an uncertain future. They were beaten in all four of their encounters under Guardiola's predecessor, Manuel Pellegrini, including elimination in the last 16 in 2014 and 2015.
Making his first start in a month after recovering from a groin injury, Messi set the tone for another virtuoso performance with a storming run through the middle of City's half before calmly dribbling past Claudio Bravo to score.
Had defender John Stones headed home David Silva's free-kick to level before the break, the second half might have unfolded differently.
Per City's official website, he added: "There were many good things".
Messi's first goal scored against Pep Guardiola's players is the 100 th of Messi-Neymar Suarez-trio in 2016. Even a good team like Barcelona didn't have it as easy as people thought.