After thanking her parents and kids, the No Doubt frontwoman, who stunned in a midriff-baring Marchesa gown for the event, gushed over Shelton, 40, and his romantic way of helping her recover after hitting rock bottom.
During her acceptance speech, the "Used To Love You" singer credited her recent success to Shelton, her family and her children.
And love was certainly in the air for Stefani all night long, as Shelton couldn't keep his eyes off his gorgeous gal. Stefani split from her husband, and the father of her three sons, Gavin Rossdale, in August 2015.
Over the period of time, this power music couple have progressed in their relationship, which is reflected by their frequent PDA-filled outings and get-togethers.
"It's incredible to have a best friend like that guy", Stefani told Entertainment Tonight. "So I basically started pouring my heart into music, and music has saved my life.I'm so honored to be able to share my story and exchange that love back and forth [with my fans]". "It was just an incredible year for me and I'm so grateful".
Wearing a fiery red mock turtle-neck dress and gold heels, the 67-year-old lit up the red carpet with her striking looks. Oh my god!' I thought I was seeing in color, but now I'm really seeing in color. "He's an wonderful person".
"I knew I had to do it, and I knew that that's what my responsibility was, because I knew I was chosen to do that", she added.
And the "Rich Girl" singer also took the time to express her amazement at being handed the award, explaining how she "never thought" she would "make an impact".
But she did, both by focusing on her music and by turning to Shelton.