Chelsea's lead over Tottenham has been reduced to four points after this reverse so Conte's response to a setback that has thrown the Premier League title wide open was always going to be intriguing.
Meanwhile, Jose Mourinho, Manchester United's manager was understandably chuffed yesterday, proclaiming that he had found a system to halt Chelsea's seemingly unstoppable march to the title.
Antonio Conte has not had to deal with defeat often in an outstanding first season as Chelsea manager - and none carrying the significance of the loss at Manchester United.
United produced their best performance of the season against Antonio Conte's men, witg goals from Marcus Rashford and Ander Herrera giving the Red Devils a morale-boosting win.
And boss Conte pointed to what he felt have been contentious decisions against his side in matches with Stoke City, Crystal Palace and Bournemouth. They showed more desire than us and more motivation, but in this case the fault is with the coach.
"We all know you either go to the final or you don't, and so we must put 200 per cent to reach the final", he stressed.
Spurs have been brilliant in attack and resolute in defense and are now back in the picture to give a tough chase to the leaders for the 2016-17 title. "It means the coach was not able to transfer the right concentration, desire, ambition to win this game".
"The pressure is normal - I prefer to have the pressure rather than not fight for the title and to joke in very moment".
The win extends fifth-placed United's unbeaten league run to 22 games and keeps them in the hunt for a Champions League spot with Mourinho seeing signs of progress from his squad.
He said post-match: "If they'd have lost Hazard and Costa and come here to lose I'd say fair enough". But maybe, just maybe, we have seen a couple of examples in the last two matches that United are better prepared for life after Zlatan than some have given them credit for. "They are named Chelsea, but they could be named Arsenal, or Tottenham, or another one".
"The satisfaction is for different reasons", said Mourinho, whose side take a 1-1 scoreline into the second leg of their Europa League quarter-final at home to Anderlecht on Thursday.
Rashford added: "We're a team, just missing one player it doesn't cancel out everything that we've worked on throughout the week".
In Sunday's other game Liverpool moved back into third place on the Premier League ladder with a 1-0 win over West Bromwich Albion thanks to an early header from Roberto Firmino.