In a statement, the USA military headquarters in Kabul said the bomb was dropped 7:32 PM local time on a tunnel complex in the Achin district of Nangarhar province, which is where the Afghan affiliate of the Islamic State is said to be operating.

The most powerful non-nuclear bomb ever used by the United States in combat was dropped on IS tunnels in Nangarhar province. MOAB, also known as the 'mother of all bombs, ' is the largest non-nuclear bomb ever dropped in any combat and had been in Afghanistan since January.

The massive bomb terrified villagers 20 miles away across the border in Pakistan with a blast they described as earsplitting.

Afghan Defense Ministry spokesman Gen. Dawlat Waziri has said that initial analysis estimates that the explosion killed 36 ISIS militants.

Haji Mohammad Sadeq, another tribal elder said civilians in the immediate area of the Islamic State hideout "left the area long ago", while others who remained were alerted by Afghan forces through mosques. Afghan officials also said there were no civilians casualties in the bombing, which was coordinated with them. It hasn't said how much it cost to develop the bomb or how many of them exist.

The strike in Achin District was the first time that the bomb has been against an enemy combatant.

USA military authorities in Afghanistan estimate that ISIS could have up to 800 fighters in the country, with most operating in the remote eastern Nangarhar province.

Former Afghan President Hamid Karzai posted scathing criticism of the USA military on Twitter Thursday, calling the operation a "brutal misuse of our country as [a] testing ground for new and unsafe weapons" and calling on Afghans "to stop" the United States.

Inamullah Meyakhil, spokesman for the central hospital in eastern Nangarhar province, said no dead or wounded had been brought to the facility from the attack.

Afghan defense officials said after the operation that 36 suspected terrorists were killed.

"Fortunately there is no report of civilians being killed in the attack", he added.

"I want a hundred times more bombings on this group", said Hakim Khan, 50, a resident of Achin district, the site of the blast.

IS, notorious for its reign of terror in Syria and Iraq, has made inroads into Afghanistan in recent years, attracting disaffected members of the Pakistani and Afghan Taliban as well as Uzbek Islamists. The rocky landscape is dotted with caves and defensive tunnels, making it easy to hold and hard to attack, according to Nic Robertson, CNN's worldwide diplomatic editor, who has reported from the Afghan mountains.