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We review the key developments in Syria, including the stalling of the Astana talks, USA plans to work with Russian Federation on operations to stabilize the region, and military deployments that could become a flashpoint for conflict between Turkey and the YPG in northern Syria.

Tillerson in a statement released in Washington late Wednesday said the United States was "prepared to explore" the establishment with Russian Federation of "joint mechanisms" for Syria, now into its sixth year of warfare.

The United States launched a retaliatory cruise missile strike days after the onslaught in Khan Sheikhun, targeting a Syrian airbase from where it said the chemical weapons attack was launched.

Washington's participation is expected in the next round of talks in late August, where there is hope for progress, fueled by a long-anticipated Putin-Trump meeting.

"Actors in Syria must remember that our fight is with ISIS", Tillerson said.

Also, some talks were held about deploying military forces and the nationality of the peacekeeping troops that were to monitor and ensure the agreement in the four de-escalation zones.

He said such efforts would help to lay the groundwork for bringing and end to the civil war that has torn Syria apart over the past six years, and has put Russian Federation and the USA on opposing sides.

Observers think that establishing de-escalation zones could provide a safe-haven for such groups that Ankara has categorized as offshoots of the Kurdistan Workers' Party (PKK).

The three guarantors - Russia, Turkey, and Iran - are now concentrating their efforts creating three more de-escalation zones, the head of Moscow's delegation said.

Bashar al-Jaafari, Syria's ambassador to the United Nations and leader of the Syrian government delegation to Astana, attributed the failure of the meeting to reach a final agreement on "counter-efforts" of the Turkish side, reports SANA.

The change in the Trump administration's attitude to no-fly zones comes as Iraqi forces and rebel groups - with the help of the US-led worldwide coalition - make significant gains against ISIS in its two most significant strongholds, Mosul in Iraq and Raqqa in Syria.

The next high-level worldwide meeting on Syria in Astana will be held in the last week of August 2017, according to the three mediators of the peace talks (Russia, Iran, Turkey) announced in a joint statement on Wednesday.

Tillerson has said Syria's future is one without Assad in power.