With the victory, Nigeria top Group B with nine points, while Cameroon have just two points from three matches, reports Xinhua news agency.
More work lie ahead for the Super Eagles who will battle Cameroon in a return leg on Monday, September 4, 2017, at the Ahmadou Ahidjo Stadium, Yaoundé.
Mikel Obi and Victor Moses ran the Indomitable Lions ragged in Uyo.
"I am not afraid of that and I don't think about that", he said after the game.
"But we have to defend our honour".
"But we will now need to win our next three matches and expect Nigeria to lose their next three games to stand any chance". Broos admitted that Cameroon's World Cup qualification hopes have been dashed.
Nuno Rocha struck twice in five first-half minutes - the second a penalty after Dean Furman's foul on Ryan Mendes - before Erick Mathoho's mindless sending off for the visitors essentially ended all hopes of a comeback.
"We are ready for a big fight".
Broos has given up on Cameroon qualifying for the World Cup.
The fear of the Cameroonians for the trio, Ighalo, Mikel, and Moses, who recently rejoined the team finally came to reality as they turned out to be the spoilers against the reigning African Cup of Nations (AFCON) champions in the crucial home win.
Desicon Company is one of Nigeria's leading vegetable Companies in the South South.
"They actually played a fine football today; I commend them for their brilliant performances, they have made the country proud and I want them to maintain this level of play".