Hughton's Brighton side are in 14th place after recording their first win of the campaign last Saturday against West Bromwich.
Wilson initially suffered the same injury to his right knee in September 2015, during a Premier League match against Stoke City.
Bournemouth manager Eddie Howe: "It's back to basics really, the fundamentals that we know can bring us success".
Brighton will return to the Vitality Stadium next Tuesday as they face Bournemouth in the third round of the EFL Cup. The lads have worked hard this week, I think we've prepared well, so we're ready.
"But he's looking good, we haven't seen him back in training yet so there's still a way to go".
"I thought it was very special play and I hope that that's the kick-start, the confidence boost that he needs because he can be a difference-maker for us".
Brighton got their first Premier League victory last week against West Brom.
The Eagles sit rock bottom of the division with no points and no goals scored and will become the first side in top flight history to lose their first five games without scoring should the Saints win to nil.
Defoe has morphed from teenage talent to 34-year-old arch-poacher while Howe has moved into management in the 16 years in between - but the Bournemouth boss still finds himself stunned by the striker's eye for goal.
Bournemouth's need for incision was evident as Anthony Knockaert hit the game's first chance wide from 25 yards, with the hosts' domination of possession only resulting in long-range half-chances for Josh King and Marc Pugh.