Choupo-Moting broke through with the interval beckoning and, if Stoke could nurse that lead through to half-time, the pressure on Manchester United would be racked up. Stoke, meanwhile, move to 10th place and travel to Newcastle next weekend.
London clubs' erratic start to the Premier League season improved with victories for Chelsea, Tottenham Hotspur and Arsenal on Saturday but Manchester sides continued to make the running, with United and City leading the way on 10 points each.
However, all De Gea's good work was undone soon after, with Choupo-Moting once again scoring, this time with a header from a corner after weak defending from Phil Jones. Subs: Martins Indi 6, Berahino 6.
The middle trident of Herrera, Nemanja Matic and Pogba were to the fore as United pinged passes into the frontline of Lukaku, Henrikh Mkhitaryan and Rashford. He provided a handsome diagonal ball to Diouf in the build up to Stoke's first goal and made a fine interception in the second half to prevent Rashford from going through on goal.
Zouma enjoyed a decent outing against a formidable opposition in Manchester United. Mourinho's side have lost only two of their last 32 Premier League matches, so it's no surprise that United to not lose is available at [1.1].
But less than three minutes later, Rashford had inadvertently nodded United level, as the frontman accidentally diverted Paul Pogba's header home - by getting in the way.
Diouf offered tremendous work rate, defensive cover for Stoke and beautifully set up Choupo-Moting for the opening goal. The Cameroon global loses his marker Jones and heads the hosts level from a corner. It looks like it came off his ankle.
Marouane Fellaini suffered a knock on global duty and wasn't part of the squad who travelled to Stoke, much to Mourinho's dismay.
After Romelu Lukaku put United in front in the 57th minute, Choupo-Moting headed in Stoke's equalizer six minutes later.
These were the Cameroon striker's first goals for Stoke and came after an worldwide break that saw him endure a 4-0 thrashing by Nigeria in a World Cup qualifier.