Real said on their website that they had agreed to extend the player's contract, originally due to expire in 2020, by two years.
Isco though himself stressed his desire to stay put previously and now his signing of a new deal will put an end to further speculation about him being linked with any move away from Spain in the near future.
The attacking midfielder will now be looking to secure more regular playing time under Zidane over the course of the season.
Tottenham are in Champions League Group H with Borussia Dortmund APOEL and holders Real Madrid
If Marcelo sees out the full length of his new deal he will have spent 16 seasons at Real Madrid after joining from Fluminense at the age of 18 on November 9, 2006.
The 29-year-old joined in 2007, making nearly 300 appearances as Real have maintained their status as one of the most successful clubs in world football.
"I knew the situation regarding gametime when I was arrived at the club", Ceballos told BeIn Sports after the match.
Marcelo confirmed that his compatriot Roberto Carlos was his top figure and helped him a lot and gave me many tips when I got here and made things easier for me.