The United manager is insistent that his team's success or failure will not depend exclusively on the form of their main striker, pointing out that they only finished sixth in the Premier League last season despite the contribution of Zlatan Ibrahimovic, who scored 28 goals in all competitions.
Jose Mourinho was determined to secure the signature of a central defender this summer, and was understood to be a big fan of United's academy graduate.
Ronald Koeman did not use his full strength in Italy, but with a team boasting the likes of Wayne Rooney, Gylfi Sigurdsson, Morgan Schneiderlin, Leighton Baines and Michael Keane he would have expected better.
Romelu Lukaku, who has scored four league goals this season, will be leading United's lines against his former club.
Rooney himself has had a fortnight to forget after his arrest on suspicion of drink driving and the fact he's seen his side ship six goals without reply in the last two games.
He'll want to score a goal and put on a performance and he'll want Everton to play well.
"We're unbeaten with eight points from four games so it's a fantastic start to the season".
United's league record had been flawless until they were held to a 2-2 draw at Stoke last Saturday, although the disappointment of conceding twice was mitigated by the impressive scoring form of Lukaku and Marcus Rashford.
"We know him really well", Koeman said of Lukaku. The Spaniard's playing style is most similar to that of last season's world record signing where he too looks to make a nuisance of himself in both penalty areas.
"In the end, I came to the decision of joining Everton and I am thankful I did that because it is going to be the best thing for me in the long run".
"But I think he also deserves credit for that because of the way he plays, the way he is committed, what he does with and without the ball, not just the last touch and the goal but his overall contribution".
United enter the contest without Paul Pogba, who limped off the pitch against Basel and won't be fit for a few weeks.
"He is injured and he can not play on Sunday", Mourinho said.