The striker could be out for a while after breaking his ribs during a vehicle crash in Amsterdam on Thursday night.
Pep Guardiola has announced Sergio Aguero will not be able to play against Chelsea on Saturday or for Argentina in the upcoming worldwide break, after breaking a rib in an accident in Amsterdam on Thursday night.
The Argentine, 29, was reported to be in a taxi on his way to the airport after watching singer Maluma perform.
Manchester City boss Pep Guardiola has played down Sergio Aguero's midweek trip to Amsterdam so close to their crunch game with Chelsea.
Manchester City, now top of the English Premier League, face championship rivals Chelsea on Saturday.
City will comment on the extent of Aguero's injury in due course. Aguero was named in Argentina's squad for their final two World Cup qualifiers against Peru (5 October) and Ecuador (10 October).
Chelsea won the Premier League with two games to spare last season as Manchester City could only muster a third-place finish.
Sergio Aguero was in Amsterdam for a concert when the accident happened.
Whereas the west London club did not return home until the early hours of Thursday morning, City's players have had time to rest up since their 2-0 home win over Shakhtar Donetsk on Tuesday.
"I've broken a rib, now I'm resting". "When we were skidding we hit a post".
"Bad news guys - I'll be joining Injury FC on loan for a couple months with ruptured ACL... but will be back soon and stronger hopefully", tweeted Mendy. "I'll be discharged in a little while".
"I think his goalscoring is quite remarkable and he is a player that thrives on pressure".
Premier League leaders City take on the champions having won their last seven games in all competitions and sit three point ahead of Antonio Conte's men at the summit.
City's swaggering start to the season has won plenty of admirers, with Pep Guardiola's free-scoring side installed as favourites to dethrone Chelsea.
There is a sense of City becoming an irresistible force under Guardiola and Leroy Sane's development into a left winger with the pace, power and goal-threat of Gareth Bale should not go unnoticed amid the goal rush.