Newcastle United winger Christian Atsu will miss out of the game after suffering a knee injury.
He was expected to return for the clash against the Black Stars but due to a tight work schedule, he says he won't make it.
"Everyone knows the hard situation we find ourselves in the campaign", Appiah was quoted as saying by Ghanasoccernet on Tuesday.
The uganda coach told Kumasi-based Nhyira FM that they were noth bothered about the players Ghana would parade in Kampala, as all they want is victory over the Stars.
Black Stars coach James Kwasi Appiah has dropped skipper Asamoah Gyan from the team to face Uganda Cranes due to injury.
Head coach of Black Stars, Kwesi Appiah, says his players are in "high spirits" ahead of their crucial Federation Internationale de Football Association 2018 World Cup qualifier against Uganda at Mandela National Stadium, Namboole on Saturday. Your best bet is to check who is showing the game in your country, and if they have an online service or iOS/Android app to watch it on.
"We are still monitoring the other players before the game on Saturday and that is why it is a national team".
"Players that are in now, their confidence levels are rising slowly and for that reason I believe when they go out there, there's not too much pressure on them", Appiah said, adding the players will be looking to "express themselves" on the pitch.
Uganda are now second on the Group E log on seven points, two shy of group leaders Egypt who host bottom side Congo on Sunday.