The Giants answered that with a 48-yard touchdown pass from Manning to receiver Odell Beckham make it 22-17. NY missed the 2-point conversion attempt after being hit with a delay of game penalty.

The Chargers brought back veteran kicker Nick Novak this week to replace Younghoe Koo, a rookie who started his career by making just one of his first four field-goal attempts.

This is the Giants' worst start since the 2013 season.

The Chargers' winning score came after defensive end Melvin Ingram sacked and stripped Giants quarterback Eli Manning to give his team the ball on the 11-yard line.

Remember when Eli Manning refused to play for the San Diego Chargers?

In the battle of quarterbacks drafted and traded for each other in 2004, Rivers was 21 of 44 for 258 yards with the three TDs and one INT. Manning was 21 of 36 for 225 yards and two TDs and the one INT. However, the Giants were hit with a delay of game penalty when they tried to line up for the 2-point conversion; after the penalty, Manning's pass to Beckham failed. The Chargers haven't been to the postseason since 2013, and less than a fifth of that roster is still around.

While accepting the Ernie Accorsi Humanitarian Award back in April, Manning took a jab at the Chargers' current Los Angeles confines while thanking the former Giants general manager for making the trade that brought him to NY.

WR MISERY: Giants WRs Sterling Shepard and Brandon Marshall left the game on the same second-quarter series with sprained left ankles. The cornerback has played well this season, but is still looking for his first interception after leading the league in picks past year.