Meyers wasn't the only host across the late night dial to address Marshall Mathers' rap, however, as Jimmy Kimmel also name-dropped the rapper in his opening monologue.
In what is perhaps the fiercest and the most exhaustive attack against Trump, Eminem called the President everything from "Donald the b--" to a "racist grandpa" during the 4.5-minute freestyle rap. "And any fan of mine who's a supporter of his/I'm drawing in the sand a line/You're either for or against/And if you can't decide who you like more in your split/ Or who you should stand beside/I'll do it for you with this/F- you".
Eminem's video has already gone viral, for obvious reasons.
Eminem is facing backlash from fans after unleashing his scathing anti-Trump freestyle.
"Do you support him?" the NBC host continued.
"I'm Seth Meyers and I'm here to say: if you like Trump, then go away", he said in a pseudo-rap response to Eminem before putting up his middle finger.
Colin Kaepernick - who started the demonstrations by "taking a knee" previous year - thanked Eminem for the song's reference to his ongoing protest on Twitter.
"Used to be a big Eminem fan".