The former Southampton defender has not played since suffering the injury in a pre-season game against Tranmere Rovers in July, and could now be out until mid-February.
He did resume light training in September, but the 26-year-old has since suffered a setback and has now undergone "minor, corrective surgery" in a bid to rectify the problem.
Some cynics will say that Saturday sees Liverpool's current team taken on Liverpool's team of tomorrow.
Jurgen Klopp's confirmed that Liverpool now need to run tests on Mane to determine how bad his setback is.
Liverpool's head of medicine Andy Massey travelled with Clyne to London after deciding the surgery was the best option.
Liverpool have missed Clyne's influence at the back with youngsters Joe Gomez and Trent Alexander-Arnold filling in at right-back.
Not only does he have to get into form, he will need to dislodge Kyle Walker and Kieran Trippier who have established themselves in the England squad over the last few months.