Marco Verratti is suspended for Monday's game with Italian defender Leonardo Bonucci wearing a protective mask after breaking his nose in a bruising first leg against Sweden in Stockholm.
With seconds left, Italy forced a corner, but when the final whistle blew there was nothing but a chorus of boos from the Italian supporters as their team's World Cup dreams were ended.
Italy dominated possession despite the defeat and will be confident of overturning the deficit, but it will undoubtedly be a nervy night at the San Siro.
Sweden advanced to its first World Cup since 2006.
"It is an important game for the history of our national team". Now, they join The Netherlands as football juggernauts who won't even make an appearance in Russian Federation.
Sweden's success, meanwhile, is likely to prompt calls for Zlatan Ibrahimovic to return to the worldwide fold.
Ibrahimovic is yet to return from the knee injury he suffered for United last April.
The makeup of next year's World Cup finals may have looked a lot different had Federation Internationale de Football Association been bold enough to implement the Video Assistant Referee (VAR) system for the qualifiers for Russia 2018. The first rule is not to cry over it.
And now we have the catalogue of penalty appeals during this Italy-Sweden clash, all of which were overruled by Lahoz.
"I expect a full San Siro to carry this team through".
This will be only the second World Cup missed by Italy.
It's make or break for the Azzurri tonight as they go into the pivotal qualifier 1-0 down against the Swedes.
"We need to be as clear headed as possible to go to the World Cup", said captain Buffon, who conceded a goal by Swedish substitute Jakob Johansson that was deflected by Daniele de Rossi.
Sweden was leading 1-0 from the first leg and held on strong to deny Italy any chance of scoring.