Should Monday's blockade - that saw the coalition force the closure of all of Yemen's borders - continue, says the United Nations, it would bring millions of people closer to "starvation and death".
One of the missiles hit a residential area near the ministry, wounding at least eight civilians, it said. "Everyone was afraid. Minutes later, another strike hit my neighbour's house", resident Mohammed Aatif said.
He also explained that the Saudi side had offered clarifications concerning the decision of temporarily closing all land, sea and airports in Yemen to stop Iranian weapons from reaching Houthi insurgents.
The Saudi-led military coalition carried out two air strikes on the defence ministry in Yemen´s rebel-held capital Sanaa late Friday, witnesses said, cited by AFP.
Witnesses said the number of casualties may rise as wounded are pulled from the rubble.
Al-Mouallimi said that the Kingdom has already presented a letter to the Security Council concerning last Saturday's ballistic missile fired from Yemen on King Khaled International Airport.
Saudi Arabia fears that the rebels will give its Shi'Ite rival Iran a foothold in the Arabian Peninsula. Medical experts also warn that the blockade will worsen the country's cholera outbreak, which has affected nearly 1 million people. "It will be the largest starvation the world has seen for many decades, with millions of victims".
The conflict has left more than 8,650 people dead, including many civilians.
Concerned by the rise of the rebels, who are allegedly backed by Iran, Saudi Arabia and a coalition of Sunni Arab states launched a massive air campaign in 2015 aimed at reinstalling President Abd-Rabbu Mansour Hadi's government.