In addition to slurring multiple words, the president ended his speech with "God bless Israel". People had their theories, but one that stuck was rather odd: Dentures. "This used to happen to my grandfather all the time". "His dentures started falling out and he wouldn't be able to finish a sentence. That's what would happen!"
"Think about it. Fake teeth, fake hair, fake tan".
In the hours since, #DentureDonald has taken over Twitter and thousands have joined in on the fun. During a televised speech summarizing his trip to Asia last month, Trump appeared to have trouble breathing and stopped to drink from a bottle with two hands.
What about his mental health?
The debate over Trump's mental health has been ongoing, especially after a group of experts who studied his behavior concluded that he shows symptoms of paranoia and personality disorders.
Trump has had difficulty speaking during a couple recent addresses.
"You know what, okay, maybe we're being mean, maybe it wasn't as bad as it seemed".
Pressed on whether the slurred words might indicate any health concerns, Shah said: "I know what you're getting at".
However, others are calling these diagnoses unfair and irresponsible.
Some psychiatrists have flouted industry rules on diagnosing public figures to openly question whether Trump is suffering from dementia or narcissistic personality disorder.
Press secretary Sarah Sanders also dismissed what she called "ridiculous questions" about Trump's health after he seemed to slur some words in a speech a day earlier.
The White House says his garbled speech was nothing more than a case of "dry mouth" and that his "throat was dry", and added, "There is nothing to it". "There's nothing to it".