Mohamed Salah was set to become one of the stars of the World Cup, but he began Egypt's first match on the bench and would never make an appearance and his country would go on to lose in heartbreaking fashion.
Egypt face Russian Federation, who beat Saudi Arabia 5-0 in their opener, on Tuesday and Salah should start.
Likewise, Egypt will have to be about more than Salah if they are to win the shoot-out between the superstars: West Brom's Ahmed Hegazy and the Arsenal midfielder Mohamed Elneny are among those charged with bolting the door for a team that tends to do its best work on the counter.
Despite Uruguay being ranked 31 places higher than Egypt which is ranked 14, the focus will remain on Egyptians, who are making the much-anticipated return to World Cup finals for the first time since the 1990 edition.
The victory sees Uruguay move up to three point and in second position in Group A behind Russian Federation.
When is the World Cup Egypt vs Uruguay match?
For Uruguay, look no further than Luis Suarez, who remains a key man for La Celeste.
There were positive signs in their first friendly in March though, with a Mohamed Salah goal giving them a surprise lead against Portugal, but the European champions roared back with two stoppage-time goals from Cristiano Ronaldo to turn the match on its head and secure a 2-1 win.
But Cuper, who is credited for rebuilding an ailing side, is adamant his side would do better at the World Cup, playing down the significance of any unfavorable results in friendly matches.
World Cups reward streaks of form that, at club level, would seem relatively moderate in length, and that is why Friday's game provides such intrigue.
Uruguay had 57-percent possession and four shots on goal, but it's a game the team could have had in the bag earlier.
Which TV channels will broadcast FIFA World Cup 2018 Egypt vs Uruguay match?
"He was fit to play against Uruguay but the coach did not want to take the risk", said the EFA.
Egypt's Amr Warda (left) challenges for the ball with Uruguay's Giorgian De Arrascaeta during their Group A match.
I'm predicting that Salah will be heavily involved for Egypt's next game against Russian Federation next week.
"Mo Salah is an extremely important player for us, nobody can deny that, but you need to have a good team, and we have a good team", Cuper said after the game. This media house does not correct any spelling or grammatical error within press releases and commentaries.