Following a corner, Ronaldo rose up, but it was the unmarked Pepe, 35, who sent home the header from behind, as the oldest Portugal player to score at a World Cup and for the first time here in Russian Federation to strike a ball into the net of Uruguay.
Portugal had 61 percent of the possession and four times as many shots at goal as the Uruguyans but Tabarez dismissed possession as a mere statistic and said what mattered was creating and converting chances.
"There is another tournament starting in September and of course we hope Cristiano will be with us to help the younger players grow", Santos said.
But three substitutions that brought on Corentin Colliso, Nabil Fekir and Florian Thauvin for Mbappe, Griezman and Blaise Matuildi handed back the initiative to Argentina who scored a consolation goal through Sergio Aguero. "Your greatest mistake was to visit matches".
"If each one of us manages to do what we know we can, then we can achieve this". She also became a mother to Ronaldo's sons, who were born from surrogate mothers earlier.
"In football, there are no moral victories and I would have preferred to play worse and win the match".
Les Bleus finally showed what they're capable of with a fantastic attacking display in a 4-3 last-16 defeat of Argentina.
The star striker managed four goals in Russian Federation, including a stunning hat-trick in the opening game against Spain.
Portugal have not lost a competitive match with Ronaldo in the side since the 2014 World Cup, although they were beaten on penalties by Chile at last year's Confederations Cup.
Later, in the other pre-quarterfinal, Portugal went down against Uruguay, riding on an excellent brace by Edinson Cavani at Sochi.
Cavani is now the second highest capped Uruguayan player to feature in World Cup matches with 15, just one behind goalkeeper Fernando Muslera.
A low-key start and an 89th-minute victor that gave them a forgettable 1-0 win over an Egypt side missing Mohamed Salah has now given way to real hope they can win their third World Cup. That will put a lot of pressure on Luis Suarez to deliver.
"But I think we have a really good defense to control him - but not just one player, the (whole) France team".
But in this topsy-turvy World Cup, one thing for Uruguay has notably changed. This is their third World Cup together.
"We want to stop them playing, make their strikers uncomfortable, that's our weapon".