Cavani now has three goals at the World Cup, but limped off in the 70th minute with an apparent injury and had to be replaced.
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The star of the game that sent Cristiano Ronaldo's team back home was Paris Saint-Germain's striker Edinson Cavani, who opened the score with an awesome header on the 7th minute, following an fantastic cross-field assist by Barcelona's Luis Suárez.
He told the BBC: 'Cavani injured is a national disaster.' Uruguay coach Oscar Tabarez confirmed on Saturday night that Cavani was injured.
But parity did not last long, Cavani steering a brilliant curling finish into the corner after 62 minutes following Bentancur's beautifully-weighted pass into his path.
"It's exciting. there are no words to describe this".
After scoring two wonderful goals either end of a Pepe header, Cavani picked up an injury and was unable to continue in the Round of 16 game between Uruguay and Portugal.
Uruguay will advance to the quarterfinals and will face France next. He was helped to the sideline with his arm around Ronaldo's back.
"No team can win with one player alone", Portugal coach Fernando Santos said. "But you always want to win, and we lost, so well done to Uruguay for making it through".
Uruguay, who included a fit-again Jose Giminez to partner captain Diego Godin dealt diligently with the set-pices employed by Ronaldo.
"We know that they were tight in the midfield, so we had some players playing wide to try to unblock the Uruguay defence".
The second match of the knockout stage between Uruguay and Portugal began on a high note, with fans hoping to see Ronaldo work his magic on the field.