The film earned positive reviews from critics and younger audiences, but also faced a fair amount of animated competition from both "Hotel Transylvania 3" and "Incredibles 2", which is still going strong in its seventh weekend and headed toward the $1 billion mark.
According to reports, Cruise's latest film crushed at the box office, primarily, with Generation X. The film did the best with the demographic between 35 and 49.
Let me start with the most important thing first: Mission: Impossible - Fallout is a monster home-run of a movie.
Elsewhere, Lionsgate's "Blindspotting" grossed an estimated $468,000 on Friday at 523 North American locations in a limited opening.
"Mission: Impossible - Ghost Protocol", aka M:I-4, has the current overall franchise record with $694.7 million worldwide, followed by "Rogue Nation" with $682.7 million, and "Mission: Impossible II" with $546.4 million.
"Rogue Nation" filmmaker Christopher McQuarrie returned to write and direct "Fallout", making him the first person to take the reins of more than one movie in the franchise.
Other than Cruise, it also stars Henry Cavill, Ving Rhames, Simon Pegg, Rebecca Ferguson, Sean Harris, Angela Bassett, Vanessa Kirby, Wes Bentley, Frederick Schmidt with Michelle Monaghan and Alec Baldwin.
Among holdovers, Sony's "Hotel Transylvania 3: Summer Vacation" brought in $31 million, where it's open in 55 overseas markets.
The animated "Teen Titans Go!". That takes its total to $165 million internationally and $284.2 million globally. It launched domestically with $10.5 million. "To the Movies", $10.5 million ($1 million international).
"Teen Titans Go!", with a surprising 91% approval on Rotten Tomatoes, is based on the DC Comics television series created by Michael Jelenic and Aaron Horvath. Here We Go Again, which fell 57 per cent in its second weekend in theatres, to earn U.S. $15 million. "Here We Go Again" just barely lost the top spot last week to "The Equalizer 2", and this week it's No. 2 again, but it managed to barely top Denzel Washington's sequel.