Despite the dramas, seven-time women's champion Serena Williams is a fan of the tradition. Her exit means eight of the top 10 seeded women have gone out before the end of Week 1.
Williams is the fourth former women's champion to get knocked out, joining Maria Sharapova, Petra Kvitova and last year's victor Garbine Muguruza.
No. 2 seed Nadal, a two-time champion, tries to get back to the quarterfinals at the All England Club for the first time since 2011, meeting 93rd-ranked Jiri Vesely of the Czech Republic, while No. 12 Djokovic, who's won Wimbledon three times, meets 40th-ranked Karen Khachanov of Russian Federation.
De Minaur downed Italian Marco Cecchinato in four sets followed by another four-set victory over Frenchman Pierre-Hugues Herbert to advance to face the recently crowned 11-time French Open champion. "It is the most special court in the world for me". I know on the women's side more so. "But I just wanted to make him think about my game style".
"I've got to work harder, get better, and hopefully next time I get the same opportunity I can push him harder. I didn't feel the effect this time".
In the women's draw, seven-times victor Serena Williams overcame her first big test in confident fashion by beating France's Kristina Mladenovic 7-5 7-6 (2).
The "Manic Monday" that opens the Wimbledon second week is probably the most interesting day in the tournament, as all the 16 fourth round singles matches - eight on the men's side, eight on the women's - take place.
Switzerland's Belinda Bencic, a former top 10 player whose ranking slumped out of the top 300 past year after wrist surgery, made the fourth round for the second time with a 6-1, 7-6 (7/3) win over Spain's Carla Suarez Navarro.
A series of unexpected results have seen Garbine Muguruza, Maria Sharapova, Simona Halep, Petra Kvitova, Venus Williams and Caroline Wozniacki all eliminated.
He was in total command opening up on Centre Court, breaking De Minaur five times in total, and on this evidence looked a decent shot to win a third Wimbledon title.
It is a remarkable record sure to alarm her opponents, but Williams, seeded 25th after her maternity leave, admits that fear factor can be a double-edged sword.
"Serena is my idol, " Rodina said.
"It was a positive match against a player with a lot of energy", said Nadal, the 2008 and 2010 champion.
I really enjoyed it. Playing on Centre Court is always like a dream and a great experience.
Serena Williams and seventh-seeded Czech Karolina Pliskova both won on Friday to avoid this year's surprising cull of favourites.