Griezmann may not be connected to Uruguay through his immediate family, but all throughout his footballing career, he's had support from a number of Uruguayan coaches and players.
Uruguay's Edinson Cavani has always played second fiddle to his more illustrious attacking colleagues at country or club level but the long-haired marksman emerged out of those shadows with his twin strike in the World Cup round of 16 last week. And when Uruguay got its chance to counter, it was deadly with the combo of Suarez and Cavani.
Cavani then had to be helped off by Ronaldo before watching the rest of the game from the dugout with ice on a calf injury.
Portugal were knocked out at the hands of Uruguay after Edinson Cavani's brace ensured a 2-1 passage to the quarter-finals.
At 33, many feel we have seen the last of Ronaldo the World Cup, although the player himself shunned questions on the issue after the defeat against Uruguay.
"There is another tournament starting in September and of course we hope Cristiano will be with us to help the younger players grow", Santos said.
Meanwhile, European champions Portugal go home, as Ronaldo and Lionel Messi bow out of the competition on the same day. "In the World Cup, it is a different mentality", he said.
"The team will continue to be one of the best teams in the world".
Russian Federation 2018 was the 33-year-old's third World Cup and it's unlikely he will be available for Qatar four years time.
"We know that they were tight in the midfield, so we had some players playing wide to try to unblock the Uruguay defence, In the first half we did it less well".
As he took his leave of the tournament, Ronaldo was in no doubt that Portugal had done the very best they could: "Generally speaking, we can be proud of our efforts".
Both the former Napoli forward and Suarez missed the first two qualifiers against Bolivia and Colombia back in 2015, but Uruguay won those games comfortably, without conceding a goal.
"We are here to play all seven matches, right up until the final, and we will see what happens", he said.