The match was also just shorter than a Davis Cup first-round match between Argentina's Leonardo Mayer and Brazil's Joao Souza, which went on for six hours and 43 minutes in 2015r.
"It was really tough for both of us".
"For us to be out there this length of time - I mean, not just on us, but coming back trying to compete at this sort of stage, going through this - it's happened to John before, when he's played another five hours".
Twitter was abuzz with jokes that the Anderson-Isner match could well stretch beyond the 70-68 final-set scoreline that Isner won with over Mahut eight years ago.
The 31-year-old Serb, who leads their head-to-head series 26-25 but trails 12-17 in Grand Slam titles, has been in the doldrums for a year but in the past fortnight has rekindled the inner fire that once enabled him to barge Roger Federer and Nadal aside at the top of men's tennis.
The pair will face off for a record 52nd time in their careers in the other men's semifinal on Friday evening.
When the match does resume Saturday, the players will have to agree whether to continue play under the same conditions, with the roof closed, or to have it open.
Each player held his next serve before Anderson broke Isner again to go up 5-4 and then proceeded to serve out the set to send the match to a decisive fifth set.
Fast facts: Isner leads Anderson 8-3 in head-to-head matchups on the ATP tour.
Nicole Melichar and Kveta Peschke upset sixth seeds Gabriela Dabrowski and Yifan Xu 6-3 4-6 7-5 in two hours and 16 minutes to reacjh the women's doubles final.
It was the kind of tennis that Wimbledon's Centre Court crowd would gladly have watched all night long.
Reflecting on the gruelling game, Anderson called on grand slam authorities to consider changing the format of matches. The most important came with Isner serving at 24-24. Anderson won the opening set before Isner bounced back to take the next two.
The American fends off another break chance at 10-10 and this insane encounter has turned into the longest Wimbledon semi-final in terms of time and the number of games, passing the insane semi-final clash between Goran Ivanisevic and Richard Krajicek that Goran won 15-13 in the fifth.
"You feel like this is a draw for the two of us, but somebody has to win."
It is a match that featured 102 thunderbolt aces, 264 unreturned serves and 247 bone-rattling winners but none of those will stand out as much as the heart and desire of the two combatants as both tried to reach to a first Wimbledon final.