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The health condition of senior most Dravida Munnetra Kazhagam leader and five-time chief minister of Tamil Nadu M Karunanidhi is deteriorating with every hour, says a bulletin released by the Kauvery Hospital at 4:30 pm on Tuesday.

The state has declared a seven-day mourning and a public holiday Wednesday.

1957: First elected to the Assembly from Kulithalai, the first of 13 times he was to be elected to the House in his lifetime.

Mr Karunanidhi was admitted to Kauvery Hospital on July 28 after suffering a drop in his blood pressure and a urinary tract infection. Karunanidhi followed Annadurai, establishing the Davidar Munnetra Kazhagam (DMK) in 1949. "Despite best efforts of our doctors and nurses to resuscitate him, he failed to respond", said Kauvery Hospital, confirming the saddening news. It's been a long journey for the his clan that made it to the top of Tamil Nadu politics.

Prime Minister Narendra Modi immediately tweeted condolences to Karunanidhi's family, saying "India and particularly Tamil Nadu will miss him immensely".

Women could be seen weeping while others held up lit candles, chanting "Kalaignar, Kalaignar".

His popularity rivalled that of J. Jayalalithaa, another powerful leader from Tamil Nadu whose death sparked a huge outpouring of grief. Asked once which one role would he choose among his many facets - politician, litterateur, film personality or social activist - Karunanidhi replied that politics was the fount for every other interest of his. His demise marks the end of an era in Tamil Nadu and India lost one of its worthiest sons, said Patnaik.

In 1974, about 14 years before the Union government's Sarkaria Commission studied Centre-state relations, the DMK government under Karunanidhi passed a resolution in the Tamil Nadu Assembly on state autonomy based on the recommendations of the Rajamannar Committee.

DMK chief Karunanidhi is on continuous monitoring and being treated with active medical support, the hospital added.

"We had met CM and submitted a request for a "Samadhi" near Anna memorial, he had accepted our request then, but has not communicated anything in this regard till now: Durai Murugan, DMK principal secretary, said". He kept his party going with a string of political agitations, through letters and appeals to his cadres in the party organ "Murasoli", rarely going out of the headlines and projecting himself as the ultimate guardian of Tamil interests world-wide.