In several videos posted to social media over the past week, crowds of dissidents are heard chanting, "Death to the dictator" as the United States prepared to reinstate sanctions on the country following President Donald Trump's exit from the worldwide nuclear deal in May.
Iran's Labour Minister Ali Rabiei was impeached on Wednesday after months of mounting anger over the government's handling of an economic crisis which has deepened with the return of U.S. sanctions.
They target USA dollar financial transactions, Iran's automotive sector and the purchase of commercial planes and metals, including gold.
Iranian Foreign Minister Mohammad Javad Zarif was cited by an Iranian newspaper, as saying that a United States plan to stop Iranian oil exports will not succeed.
The US is making history not just by violating a United Nations security council resolution it voted for three years ago, but also by penalising countries who stick to the same unanimous resolution, the Iranian ambassador to the UN has claimed.
USA officials have said in recent weeks that they aim to pressure countries to stop buying oil from Iran in a bid to force Tehran to halt its nuclear and missile programs and involvement in regional conflicts in Syria and Iraq.
The first wave of United States sanctions took effect on Tuesday.
In November, a second batch of potentially more damaging sanctions will be reinstated on Iran's port operators, and the energy, shipping, and shipbuilding sectors.
"The performance of the USA government over the years is such that today the United States is recognized as an unreliable country in the world that does not adhere to any of its obligations", the President said, calling for the "expansion of relations and cooperation" between Tehran and Pyongyang.
"You have all these different pressures and people are getting upset and for the most part, from what we can tell, they're blaming the regime and they're not really blaming the U.S.", Politico foreign affairs correspondent Nahal Toosi said on the Bill Press Show.
Iranian President Hassan Rouhani has vowed that Iran will stand firm against threats by the United States over oil shipments, after Washington reimposed economic sanctions on the Islamic republic. "We can't get drawn into a confrontation with America by falling into this war room trap and playing on a battlefield".
Last month, Trump offered to meet Iran's leaders.
Signed in 2015, the landmark deal was meant to lift sanctions against Iran in return for curbs in its nuclear programme.
Europeans, also signatories to the JCPOA agreement, have said they are determined to save the text, with the EU saying on Tuesday it aimed to "protect European economic operators engaged in legitimate business with Iran".