Spain followed its gritty 2-1 win against England at Wembley Stadium last week with a 6-0 rout of World Cup runner-up Croatia on Tuesday, keeping Enrique flawless since taking over as La Roja's coach.
Croatia's best moment came before the first whistle even blew. Two matches, two convincing wins against top opponents in the UEFA Nations League.
Spain, meanwhile, is coming off a 2-1 victory over England in its first Nations League match.
Croatia, which lost the World Cup final to France, fell apart after defender Sime Vrsaljko had to be substituted due to an injury just minutes before Spain's first goal.
The UEFA Nation's League match between Spain and Croatia will be broadcast live on ESPN2 and Univision Deportes.
Manager Zlatko Dalic and his team of World Cup finalists could sit back on Saturday evening and watch their League A Group 4 rivals go head-to-head at Wembley.
The former European and World Cup winners trained on Monday ahead of the game where they will be looking to build on their flawless start after beating England 2-1 on Saturday. Their inclusion made Luis Enrique the first Spain coach in 16 years to name six Real Madrid players in a starting lineup, making a mockery of fears in the Spanish media when he was appointed that he would discriminate against Real players over loyalty to his former club Barcelona.
Croatia midfielder Ivan Rakitic wasn't too happy with his team's performance against Spain.
The hosts will need to be in better form against Romelu Lukaku and Eden Hazard than in their last game, the first without influential manager Heimir Hallgromsson, where they were beaten 6-0 by Switzerland.
Croatia is the 2018 World Cup runner-up, winning its group that included Argentina before beating Denmark, Russia and England on the way to the final.